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Spotlight on Prostatic Intraepithelial Neoplasia

After visiting a urologist for a prostate biopsy, some men receive a pathology report that mentions the presence of prostatic intraepithelial neoplasia (PIN). Continue reading for more information about the PIN in prostate cells and to learn about the basics of this diagnosis.


PIN refers to abnormal cells that are taken during a prostate biopsy, and it can be best described as a precancerous condition. If your pathology report mentions that PIN was found, then this means that changes were seen in the appearance of the prostate cells. However, these abnormal cells do not look as if they are growing into other areas of the prostate like cancer cells would.


If the PIN is detected in the cells taken during your prostate biopsy, then it will be classified as either low-grade or high-grade. Low-grade PIN means that the patterns of the prostate cells appear nearly normal. The presence of high-grade PIN indicates that the prostate cells appeared more abnormal.


The PIN can begin to show up in the prostate cells of men that are in their 20s. Also, it’s not unusual for men to develop low-grade PIN at a young age that does not progress to prostate cancer. In fact, it’s unclear to urologists exactly what link there is between a low-grade PIN and prostate cancer. On the other hand, if a high-grade PIN is detected in your prostate cells, then the chance that there is cancer in another area of your prostate is about 20%.


If the PIN is detected in your biopsy, then speak with your urologist about what steps to take next. For most patients, an even high-grade PIN does not progress to prostate cancer. For this reason, there may be no steps for you to take before your next regular biopsy. If you’re a patient with a higher risk of prostate cancer, then your urologist may recommend a repeat biopsy.

Are you looking for a compassionate and experienced urologist in Nashville? If so, then please come and see us at Urology Associates, P.C. Call 888-656-0667 for information about our services or to schedule your appointment.